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Devi demonstrated that an alcoholic extract of the dried roots of Ashwagandha as well as withaferin A isolated from the extract showed significant antitumor and radiosensitizing effects in experimental tumors in Chinese hamsters in vivo, without any noticeable systemic toxicity.In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor
Devi and colleagues demonstrated a regression in sarcomas in rats treated with ashwagandha injections at doses of 500 to 750mg/ kg. (1. Devi 1992)Hypertensive Retinopathy Associated With Use of the Ephedra-Free Weight-Loss Herbal Supplement Hydro
A patient who took Ephedra free Hydroxycuts developed hypertension with retinopathy.Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart fa
CoEnzyme Q10 50mg daily given to 1715 patients with heart failure in addition to their conventional treatment resulted in a reduction in dyspnoea at rest and on exertion,reduction in ankle oedema,lung signs,heart rate and blood pressure after 1 month of treatment.Side effects were few.CoenzymeQ10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomised,
CoEnzyme Q10 improves quality of life in end-stage heart failure.

Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera

Date Added: April 18, 2008 05:11:13 AM

Author: Anonymous

Category: HEALTH: Medicine: Oncology

PU Devi, K Akagi, V Ostapenko, Y Tanaka, and T Sugahara Int J Radiat Biol, February 1, 1996; 69(2): 193-7.  ABSTRACT Withaferin A, a steroidal lactone isolated from the roots of the Indian medicinal plant Withania somnifera, reduced survival of V79 cells in a dose-dependent manner. LD50 for survival was 16 microM. One-hour treatment with a non-toxic dose of 2.1 microM before irradiation significantly enhanced cell killing, giving a sensitizer enhancement ratio (SER) of 1.5 for 37% survival and 1.4 for 10% survival. SER increased with drug dose, but at higher doses the increased lethality appears to be due to two effects-- drug toxicity and radiosensitization. The drug induced a G2/M block, with a maximum accumulation of cells in G2-M phase at 4 h after treatment with 10.5 microM withaferin A in 1 h. The applicability of this drug as a radiosensitizer in cancer therapy needs to be explored

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