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Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera

Date Added: April 18, 2008 05:11:13 AM

Author: Anonymous

Category: HEALTH: Medicine: Oncology

PU Devi, K Akagi, V Ostapenko, Y Tanaka, and T Sugahara Int J Radiat Biol, February 1, 1996; 69(2): 193-7.  ABSTRACT Withaferin A, a steroidal lactone isolated from the roots of the Indian medicinal plant Withania somnifera, reduced survival of V79 cells in a dose-dependent manner. LD50 for survival was 16 microM. One-hour treatment with a non-toxic dose of 2.1 microM before irradiation significantly enhanced cell killing, giving a sensitizer enhancement ratio (SER) of 1.5 for 37% survival and 1.4 for 10% survival. SER increased with drug dose, but at higher doses the increased lethality appears to be due to two effects-- drug toxicity and radiosensitization. The drug induced a G2/M block, with a maximum accumulation of cells in G2-M phase at 4 h after treatment with 10.5 microM withaferin A in 1 h. The applicability of this drug as a radiosensitizer in cancer therapy needs to be explored

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